Assay Detail
Binding
CHEMBL5217003
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Inhibition of human recombinant MAO-A assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometry
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isatoic anhydrides as novel inhibitors of monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.98 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269538 | HARMINE | 1.0 | 1 | 8.39 |
| CHEMBL5218784 | — | — | 1 | 8.02 |
| CHEMBL5219958 | — | — | 1 | 8.00 |
| CHEMBL5220349 | — | — | 1 | 7.37 |
| CHEMBL5220071 | — | — | 1 | 7.23 |
| CHEMBL5220277 | — | — | 1 | 7.21 |
| CHEMBL5218762 | — | — | 1 | 7.19 |
| CHEMBL5220869 | — | — | 1 | 7.08 |
| CHEMBL5219611 | — | — | 1 | 7.03 |
| CHEMBL5219594 | — | — | 1 | 6.91 |
| CHEMBL5218579 | — | — | 1 | 6.88 |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | 5.79 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.56 |
| CHEMBL326294 | ISATIN | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269538 | HARMINE | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5218784 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL5219958 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5220349 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5220071 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5220277 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5218762 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5220869 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5219611 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5219594 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL5218579 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL18116 | TOLOXATONE | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL140 | CURCUMIN | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL326294 | ISATIN | IC50 | = | 8430.0 | nM | 5.07 |