Assay Detail
Binding
CHEMBL5217004
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Inhibition of human recombinant MAO-B assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isatoic anhydrides as novel inhibitors of monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.42 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5220869 | — | — | 1 | 8.33 |
| CHEMBL5220277 | — | — | 1 | 8.19 |
| CHEMBL5218784 | — | — | 1 | 8.16 |
| CHEMBL5220071 | — | — | 1 | 7.96 |
| CHEMBL5220349 | — | — | 1 | 7.85 |
| CHEMBL5219594 | — | — | 1 | 7.82 |
| CHEMBL5219611 | — | — | 1 | 7.75 |
| CHEMBL5218762 | — | — | 1 | 7.70 |
| CHEMBL5218579 | — | — | 1 | 7.14 |
| CHEMBL5219958 | — | — | 1 | 7.12 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.59 |
| CHEMBL326294 | ISATIN | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5220869 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5220277 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5218784 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5220071 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5220349 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5219594 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5219611 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5218762 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5218579 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5219958 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL140 | CURCUMIN | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL326294 | ISATIN | IC50 | = | 3900.0 | nM | 5.41 |