Assay Detail
Binding
CHEMBL5217050
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Inhibition of PI3Kdelta (unknown origin) measured by ADP-Glo assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of PI3K/HDAC Dual-targeted inhibitors with subtype selectivity as potential therapeutic agents against solid Tumors: Building HDAC6 potency in a Quinazolinone-based PI3Kδ-selective template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.74 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5218671 | — | — | 1 | 8.80 |
| CHEMBL5218472 | — | — | 1 | 8.64 |
| CHEMBL5218681 | — | — | 1 | 8.21 |
| CHEMBL5219509 | — | — | 1 | 8.17 |
| CHEMBL5220243 | — | — | 1 | 8.16 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 8.15 |
| CHEMBL5220310 | — | — | 1 | 7.80 |
| CHEMBL5219798 | — | — | 1 | 7.75 |
| CHEMBL5218454 | — | — | 1 | 7.70 |
| CHEMBL5219657 | — | — | 1 | 7.66 |
| CHEMBL5219236 | — | — | 1 | 7.62 |
| CHEMBL5218764 | — | — | 1 | 7.48 |
| CHEMBL5221043 | — | — | 1 | 7.44 |
| CHEMBL5220434 | — | — | 1 | 7.38 |
| CHEMBL5219048 | — | — | 1 | 7.38 |
| CHEMBL5218525 | — | — | 1 | 7.12 |
| CHEMBL5218549 | — | — | 1 | 7.00 |
| CHEMBL5220934 | — | — | 1 | 6.87 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | - |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | - |
| CHEMBL5219246 | — | — | 1 | - |
| CHEMBL5220325 | — | — | 1 | - |
| CHEMBL5219356 | — | — | 1 | - |
| CHEMBL5219941 | — | — | 1 | - |
| CHEMBL5220776 | — | — | 1 | - |
| CHEMBL5221123 | — | — | 1 | - |
| CHEMBL5218504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5218671 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5218472 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5218681 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5219509 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL5220243 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5220310 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5219798 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5218454 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5219657 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5219236 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5218764 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5221043 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5220434 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5219048 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5218525 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5218549 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL5220934 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - | |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | - | — | - | |
| CHEMBL2018302 | TUBASTATIN A | IC50 | - | — | - | |
| CHEMBL5219246 | — | IC50 | - | — | - | |
| CHEMBL5220325 | — | IC50 | - | — | - | |
| CHEMBL5219356 | — | IC50 | - | — | - | |
| CHEMBL5219941 | — | IC50 | - | — | - | |
| CHEMBL5220776 | — | IC50 | - | — | - | |
| CHEMBL5221123 | — | IC50 | - | — | - | |
| CHEMBL5218504 | — | IC50 | - | — | - |