Assay Detail
Binding
CHEMBL5217051
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Inhibition of HDAC6 (unknown origin) measured by fluorescence based assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of PI3K/HDAC Dual-targeted inhibitors with subtype selectivity as potential therapeutic agents against solid Tumors: Building HDAC6 potency in a Quinazolinone-based PI3Kδ-selective template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.25 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 8.03 |
| CHEMBL5219048 | — | — | 1 | 7.96 |
| CHEMBL5218472 | — | — | 1 | 7.89 |
| CHEMBL5220434 | — | — | 1 | 7.89 |
| CHEMBL5218525 | — | — | 1 | 7.89 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 7.77 |
| CHEMBL5218764 | — | — | 1 | 7.57 |
| CHEMBL5219798 | — | — | 1 | 7.57 |
| CHEMBL5220934 | — | — | 1 | 7.55 |
| CHEMBL5218454 | — | — | 1 | 7.50 |
| CHEMBL5219657 | — | — | 1 | 7.44 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.41 |
| CHEMBL5220310 | — | — | 1 | 7.37 |
| CHEMBL5220776 | — | — | 1 | 7.35 |
| CHEMBL5218549 | — | — | 1 | 7.35 |
| CHEMBL5221123 | — | — | 1 | 7.18 |
| CHEMBL5219941 | — | — | 1 | 7.17 |
| CHEMBL5218671 | — | — | 1 | 7.06 |
| CHEMBL5221043 | — | — | 1 | 6.92 |
| CHEMBL5219509 | — | — | 1 | 6.78 |
| CHEMBL5219246 | — | — | 1 | 6.66 |
| CHEMBL5219356 | — | — | 1 | 6.57 |
| CHEMBL5218504 | — | — | 1 | 6.55 |
| CHEMBL5218681 | — | — | 1 | 6.48 |
| CHEMBL5220325 | — | — | 1 | 6.40 |
| CHEMBL5220243 | — | — | 1 | 6.22 |
| CHEMBL5219236 | — | — | 1 | - |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5219048 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5218472 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5220434 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5218525 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5218764 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5219798 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5220934 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5218454 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5219657 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5220310 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5220776 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5218549 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5221123 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5219941 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5218671 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5221043 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL5219509 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL5219246 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL5219356 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL5218504 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5218681 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL5220325 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL5220243 | — | IC50 | = | 604.0 | nM | 6.22 |
| CHEMBL5219236 | — | IC50 | - | — | - | |
| CHEMBL2216870 | IDELALISIB | IC50 | - | — | - |