Assay Detail
Binding
CHEMBL5217064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC11 (unknown origin) measured by fluorescence based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of PI3K/HDAC Dual-targeted inhibitors with subtype selectivity as potential therapeutic agents against solid Tumors: Building HDAC6 potency in a Quinazolinone-based PI3Kδ-selective template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.81 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5218472 | — | — | 1 | 5.81 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | - |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5218472 | — | IC50 | = | 1547.0 | nM | 5.81 |
| CHEMBL98 | VORINOSTAT | IC50 | > | 5000.0 | nM | - |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | > | 5000.0 | nM | - |
| CHEMBL2018302 | TUBASTATIN A | IC50 | > | 5000.0 | nM | - |