Assay Detail
Binding
CHEMBL5217075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hedgehog signalling pathway in human A549 cells assessed as reduction in Gli gene expression incubated for 24 hrs by qPCR analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and activity evaluation of Hedgehog inhibitor Itraconazole derivatives in A549 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.45 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5219278 | — | — | 1 | 7.05 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 6.90 |
| CHEMBL5219499 | — | — | 1 | 6.60 |
| CHEMBL5218534 | — | — | 1 | 6.34 |
| CHEMBL5219258 | — | — | 1 | 6.11 |
| CHEMBL5219088 | — | — | 1 | 6.07 |
| CHEMBL5219502 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5219278 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL5219499 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL5218534 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL5219258 | — | IC50 | = | 782.0 | nM | 6.11 |
| CHEMBL5219088 | — | IC50 | = | 844.0 | nM | 6.07 |
| CHEMBL5219502 | — | IC50 | = | 873.0 | nM | 6.06 |