Assay Detail
Functional
CHEMBL5217076
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Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and activity evaluation of Hedgehog inhibitor Itraconazole derivatives in A549 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.37 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5219278 | — | — | 1 | 5.69 |
| CHEMBL5219499 | — | — | 1 | 5.67 |
| CHEMBL5219502 | — | — | 1 | 5.59 |
| CHEMBL5218534 | — | — | 1 | 5.58 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 5.52 |
| CHEMBL5220797 | — | — | 1 | 5.52 |
| CHEMBL5219258 | — | — | 1 | 5.42 |
| CHEMBL5219605 | — | — | 1 | 5.42 |
| CHEMBL5218763 | — | — | 1 | 5.36 |
| CHEMBL5220836 | — | — | 1 | 5.32 |
| CHEMBL5219794 | — | — | 1 | 5.27 |
| CHEMBL5219898 | — | — | 1 | 5.18 |
| CHEMBL5219088 | — | — | 1 | 5.06 |
| CHEMBL5218819 | — | — | 1 | 5.00 |
| CHEMBL5218668 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5219278 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5219499 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL5219502 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL5218534 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5220797 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL5219258 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL5219605 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL5218763 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL5220836 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL5219794 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL5219898 | — | IC50 | = | 6640.0 | nM | 5.18 |
| CHEMBL5219088 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL5218819 | — | IC50 | = | 10010.0 | nM | 5.00 |
| CHEMBL5218668 | — | IC50 | = | 10460.0 | nM | 4.98 |