Assay Detail
Binding
CHEMBL5217151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged full length mouse LMW-PTP expressed in Escherichia coli BL21(DE3) by SDS PAGE based mass spectrometry analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Low molecular weight phosphotyrosine protein phosphatase (CHEMBL3593153) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.47 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5218807 | — | — | 1 | 8.52 |
| CHEMBL5220114 | — | — | 1 | 7.44 |
| CHEMBL5219519 | — | — | 1 | 7.21 |
| CHEMBL4794972 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5218807 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5220114 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5219519 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4794972 | — | IC50 | = | 200.0 | nM | 6.70 |