Assay Detail
Binding
CHEMBL5217290
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Inhibition of MMP-2 (unknown origin) using fTHP-15(FAM) as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a putative Zn<sup>2+</sup>-chelating but highly selective MMP-13 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.74 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081997 | — | — | 1 | 6.14 |
| CHEMBL5220833 | — | — | 1 | 6.08 |
| CHEMBL5219839 | — | — | 1 | 5.46 |
| CHEMBL5220661 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081997 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5220833 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL5219839 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5220661 | — | IC50 | = | 5100.0 | nM | 5.29 |