Assay Detail
Binding
CHEMBL5217291
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Inhibition of MMP-8 (unknown origin) using fTHP-15(FAM) as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a putative Zn<sup>2+</sup>-chelating but highly selective MMP-13 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.79 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081997 | — | — | 1 | 6.22 |
| CHEMBL5220833 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081997 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5220833 | — | IC50 | = | 4500.0 | nM | 5.35 |