Assay Detail

CHEMBL5217455

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of HDAC6 (unknown origin)

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Histone deacetylase 6 (CHEMBL1865) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Histone deacetylase 6 (CHEMBL1865) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Histone deacetylase 6

CHEMBL1865

Anchored from Assay target.

Protein identity Histone deacetylase 6

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Histone deacetylase 6 (CHEMBL1865) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer's disease.

Li Y, Lin S, Gu Z, Chen L, He B.
Bioorg Med Chem Lett (2022) 76 : 129015 -129015
PubMed 36208870 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.08	8.33

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2364628	RICOLINOSTAT	2.0	1	8.33
CHEMBL2018302	TUBASTATIN A	—	1	7.82

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2364628	RICOLINOSTAT	IC50	=	4.7	nM	8.33
CHEMBL2018302	TUBASTATIN A	IC50	=	15.0	nM	7.82