Assay Detail
Binding
CHEMBL5217466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DPP4 using Gly-Pro-AMC as substrate incubated for 30 mins by continuous fluorescent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Proline based rationally designed peptide esters against dipeptidyl peptidase-4: Highly potent anti-diabetic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.31 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | 4.0 | 1 | 9.40 |
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | 4.0 | 1 | 8.82 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 1 | 8.12 |
| CHEMBL3185489 | — | — | 1 | 7.75 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL3185489 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 34.0 | nM | 7.47 |