Assay Detail
Functional
CHEMBL5217601
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Upregulation of BCAA expression in human MDA-MB-231 cells
7
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.76 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5219349 | — | — | 3 | 6.11 |
| CHEMBL4551635 | BAY-069 | — | 3 | 6.06 |
| CHEMBL3617078 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5219349 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4551635 | BAY-069 | IC50 | = | 874.0 | nM | 6.06 |
| CHEMBL4551635 | BAY-069 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5219349 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5219349 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3617078 | — | IC50 | = | 564000.0 | nM | - |
| CHEMBL4551635 | BAY-069 | IC50 | - | — | - |