Assay Detail
Binding
CHEMBL5217615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged Keap1 kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3) cells to Cy5-Nrf2 (unknown origin) protein-protein interaction incubated for 10 to 15 mins by fluorescence polarization assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 52 | 4.69 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5219706 | — | — | 1 | 7.40 |
| CHEMBL5221116 | — | — | 1 | 6.55 |
| CHEMBL5220611 | — | — | 1 | 6.23 |
| CHEMBL5220492 | — | — | 1 | 6.20 |
| CHEMBL5219279 | — | — | 1 | 5.97 |
| CHEMBL5219716 | — | — | 1 | 5.95 |
| CHEMBL5220561 | — | — | 1 | 5.77 |
| CHEMBL5220635 | — | — | 1 | 5.77 |
| CHEMBL5220085 | — | — | 1 | 5.50 |
| CHEMBL5220416 | — | — | 1 | 5.48 |
| CHEMBL5220901 | — | — | 1 | 5.34 |
| CHEMBL5220959 | — | — | 1 | 5.20 |
| CHEMBL5218578 | — | — | 1 | 5.20 |
| CHEMBL5220988 | — | — | 1 | 4.98 |
| CHEMBL5220806 | — | — | 1 | 4.96 |
| CHEMBL5220442 | — | — | 1 | 4.70 |
| CHEMBL5220793 | — | — | 1 | 4.55 |
| CHEMBL5218545 | — | — | 1 | 4.24 |
| CHEMBL5221078 | — | — | 1 | 4.05 |
| CHEMBL5218800 | — | — | 1 | 4.04 |
| CHEMBL5219398 | — | — | 1 | 3.31 |
| CHEMBL5219654 | — | — | 1 | 2.64 |
| CHEMBL5220253 | — | — | 1 | 2.60 |
| CHEMBL5220089 | — | — | 1 | 2.58 |
| CHEMBL1602552 | — | — | 1 | 2.50 |
| CHEMBL5218544 | — | — | 1 | 2.48 |
| CHEMBL1230159 | — | — | 1 | 2.47 |
| CHEMBL5218736 | — | — | 1 | - |
| CHEMBL5219243 | — | — | 1 | - |
| CHEMBL5219586 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5219706 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL5221116 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL5220611 | — | Ki | = | 584.0 | nM | 6.23 |
| CHEMBL5220492 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL5219279 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL5219716 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL5220561 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL5220635 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL5220085 | — | Ki | = | 3190.0 | nM | 5.50 |
| CHEMBL5220416 | — | Ki | = | 3340.0 | nM | 5.48 |
| CHEMBL5220901 | — | Ki | = | 4570.0 | nM | 5.34 |
| CHEMBL5220959 | — | Ki | = | 6330.0 | nM | 5.20 |
| CHEMBL5218578 | — | Ki | = | 6310.0 | nM | 5.20 |
| CHEMBL5220988 | — | Ki | = | 10500.0 | nM | 4.98 |
| CHEMBL5220806 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL5220442 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL5220793 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL5218545 | — | Ki | = | 58200.0 | nM | 4.24 |
| CHEMBL5221078 | — | Ki | = | 88600.0 | nM | 4.05 |
| CHEMBL5218800 | — | Ki | = | 91400.0 | nM | 4.04 |
| CHEMBL5219398 | — | Ki | = | 490000.0 | nM | 3.31 |
| CHEMBL5219654 | — | Ki | = | 2300000.0 | nM | 2.64 |
| CHEMBL5220253 | — | Ki | = | 2500000.0 | nM | 2.60 |
| CHEMBL5220089 | — | Ki | = | 2600000.0 | nM | 2.58 |
| CHEMBL1602552 | — | Ki | = | 3200000.0 | nM | 2.50 |
| CHEMBL5218544 | — | Ki | = | 3300000.0 | nM | 2.48 |
| CHEMBL1230159 | — | Ki | = | 3400000.0 | nM | 2.47 |
| CHEMBL5220790 | — | Ki | = | 1450000.0 | nM | - |
| CHEMBL5219043 | — | Ki | = | 369000.0 | nM | - |
| CHEMBL5219567 | — | Ki | = | 669000.0 | nM | - |
| CHEMBL5220425 | — | Ki | = | 988000.0 | nM | - |
| CHEMBL5218847 | — | Ki | = | 1930000.0 | nM | - |
| CHEMBL5219786 | — | Ki | = | 1040000.0 | nM | - |
| CHEMBL5219949 | — | Ki | = | 1890000.0 | nM | - |
| CHEMBL5220962 | — | Ki | = | 333000.0 | nM | - |
| CHEMBL5220919 | — | Ki | = | 303000.0 | nM | - |
| CHEMBL5220527 | — | Ki | = | 163000.0 | nM | - |
| CHEMBL5218874 | — | Ki | = | 466000.0 | nM | - |
| CHEMBL5219010 | — | Ki | = | 880000.0 | nM | - |
| CHEMBL5220967 | — | Ki | = | 1590000.0 | nM | - |
| CHEMBL5220386 | — | Ki | = | 174000.0 | nM | - |
| CHEMBL5220707 | — | Ki | = | 296000.0 | nM | - |
| CHEMBL5220925 | — | Ki | = | 1960000.0 | nM | - |
| CHEMBL5218835 | — | Ki | = | 513000.0 | nM | - |
| CHEMBL5220188 | — | Ki | = | 449000.0 | nM | - |
| CHEMBL5220334 | — | Ki | = | 568000.0 | nM | - |
| CHEMBL5220612 | — | Ki | = | 387000.0 | nM | - |
| CHEMBL5219586 | — | Ki | = | 217000.0 | nM | - |
| CHEMBL5219243 | — | Ki | = | 122000.0 | nM | - |
| CHEMBL5218736 | — | Ki | = | 145000.0 | nM | - |