Assay Detail
Binding
CHEMBL5217630
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Inhibition of Keap1 kelch domain to Nrf2 (unknown origin) protein-protein interaction
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.16 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4739983 | — | — | 1 | 7.66 |
| CHEMBL4174651 | — | — | 1 | 7.22 |
| CHEMBL4646536 | — | — | 1 | 7.14 |
| CHEMBL4740287 | — | — | 1 | 7.12 |
| CHEMBL5219681 | — | — | 1 | 7.01 |
| CHEMBL4640621 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4739983 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4174651 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4646536 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4740287 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5219681 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4640621 | — | IC50 | = | 150.0 | nM | 6.82 |