Assay Detail
Binding
CHEMBL5217864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP51 in Candida albicans ATCC SC5314 assessed as reduction in substrate consumption using lanosterol as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Lanosterol 14-alpha demethylase (CHEMBL1780) ↗| Type | SINGLE PROTEIN |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Publication
Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.74 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | 6.96 |
| CHEMBL5219227 | — | — | 1 | 6.80 |
| CHEMBL5219013 | — | — | 1 | 6.72 |
| CHEMBL5220891 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106 | FLUCONAZOLE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5219227 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5219013 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5220891 | — | IC50 | = | 350.0 | nM | 6.46 |