Assay Detail
Binding
CHEMBL5217865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX2 (unknown origin) assessed as reduction in PGF2alpha content using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.63 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.75 |
| CHEMBL5219227 | — | — | 1 | 5.71 |
| CHEMBL5219013 | — | — | 1 | 5.64 |
| CHEMBL5220891 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5219227 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL5219013 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL5220891 | — | IC50 | = | 3760.0 | nM | 5.42 |