Assay Detail
Binding
CHEMBL5217994
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by substrate addition and measured by RapdiFire-MS/MS analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.56 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5220994 | — | — | 1 | 10.10 |
| CHEMBL5221053 | — | — | 1 | 10.00 |
| CHEMBL5219157 | — | — | 1 | 9.90 |
| CHEMBL5219030 | — | — | 1 | 9.80 |
| CHEMBL5219693 | — | — | 1 | 9.80 |
| CHEMBL5219667 | — | — | 1 | 9.70 |
| CHEMBL5220447 | — | — | 1 | 9.60 |
| CHEMBL5220732 | — | — | 1 | 9.60 |
| CHEMBL5220956 | — | — | 1 | 9.50 |
| CHEMBL5219678 | — | — | 1 | 9.40 |
| CHEMBL5219512 | — | — | 1 | 9.20 |
| CHEMBL5221030 | — | — | 1 | 9.10 |
| CHEMBL5220546 | — | — | 1 | 9.10 |
| CHEMBL5220332 | — | — | 1 | 9.00 |
| CHEMBL5219466 | — | — | 1 | 8.70 |
| CHEMBL5221088 | — | — | 1 | 8.30 |
| CHEMBL5219851 | — | — | 1 | 8.10 |
| CHEMBL5218875 | — | — | 1 | 8.00 |
| CHEMBL5219712 | — | — | 1 | 8.00 |
| CHEMBL5219204 | — | — | 1 | 7.80 |
| CHEMBL5219472 | — | — | 1 | 7.70 |
| CHEMBL5221117 | — | — | 1 | 7.70 |
| CHEMBL5218882 | — | — | 1 | 7.40 |
| CHEMBL5220135 | — | — | 1 | 7.30 |
| CHEMBL5218485 | — | — | 1 | 7.10 |
| CHEMBL5219575 | — | — | 1 | 7.00 |
| CHEMBL1700017 | — | — | 1 | 6.80 |
| CHEMBL5219253 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5220994 | — | IC50 | = | 0.07943 | nM | 10.10 |
| CHEMBL5221053 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5219157 | — | IC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL5219030 | — | IC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL5219693 | — | IC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL5219667 | — | IC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL5220447 | — | IC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL5220732 | — | IC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL5220956 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL5219678 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL5219512 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL5221030 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL5220546 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL5220332 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5219466 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL5221088 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL5219851 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL5218875 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5219712 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5219204 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5219472 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL5221117 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL5218882 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5220135 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5218485 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5219575 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1700017 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL5219253 | — | IC50 | = | 1258.93 | nM | 5.90 |