Assay Detail
Binding
CHEMBL5218090
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Inhibition of rat ADCY10 overexpressed in rat 4-4 cells assessed as IBMX stimulated cAMP accumulation preincubated for 10 mins followed by IBMX stimulation and measured after 5 mins by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | 4-4 cell |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.97 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5218698 | — | — | 1 | 8.72 |
| CHEMBL5220685 | — | — | 1 | 8.60 |
| CHEMBL5218878 | — | — | 1 | 8.26 |
| CHEMBL5219830 | — | — | 1 | 8.26 |
| CHEMBL5220647 | — | — | 1 | 7.97 |
| CHEMBL5218615 | — | — | 1 | 7.84 |
| CHEMBL5218702 | — | — | 1 | 7.78 |
| CHEMBL5218552 | — | — | 1 | 7.71 |
| CHEMBL5219443 | — | — | 1 | 7.64 |
| CHEMBL5219579 | — | — | 1 | 7.46 |
| CHEMBL5220632 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5218698 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5220685 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5218878 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL5219830 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL5220647 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL5218615 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL5218702 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL5218552 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL5219443 | — | IC50 | = | 22.9 | nM | 7.64 |
| CHEMBL5219579 | — | IC50 | = | 34.8 | nM | 7.46 |
| CHEMBL5220632 | — | IC50 | = | 37.7 | nM | 7.42 |