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Assay Detail

CHEMBL5218423

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to PPARdelta (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peroxisome proliferator-activated receptor delta (CHEMBL3979)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Pan-peroxisome Proliferator-Activated Receptor Modulators from an Endolichenic Fungus, <i>Daldinia childiae</i>.
Kim J, Ko H, Hur JS, An S, Lee JW, Deyrup ST, Noh M, Shim SH.
J Nat Prod (2022) 85 : 2804 -2816
PubMed 36475432 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 4 6.87 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL38943 GW501516 2.0 1 9.00
CHEMBL5219536 1 4.73
CHEMBL5220260 1 -
CHEMBL595 PIOGLITAZONE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL38943 GW501516 Ki = 1.0 nM 9.00
CHEMBL5219536 Ki = 18800.0 nM 4.73
CHEMBL5220260 Ki - -
CHEMBL595 PIOGLITAZONE Ki - -