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Assay Detail

CHEMBL5223337

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of urease (unknown origin) incubated for 30 mins by microplate reader based analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study.
Abdulwahab HG, Harras MF, El Menofy NG, Hegab AM, Essa BM, Selim AA, Sakr TM, El-Zahabi HSA.
Bioorg Med Chem (2020) 28 : 115759 -115759
PubMed 32992246 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.48 5.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5284356 1 5.09
CHEMBL5286298 1 5.00
CHEMBL5278737 1 4.96
CHEMBL5284048 1 4.87
CHEMBL5276654 1 4.77
CHEMBL260876 THIOUREA 1 4.70
CHEMBL5289402 1 4.68
CHEMBL5287120 1 4.64
CHEMBL5268072 1 4.57
CHEMBL5284254 1 4.53
CHEMBL5268337 1 4.35
CHEMBL5273256 1 4.28
CHEMBL5278896 1 4.26
CHEMBL5290409 1 4.22
CHEMBL5281292 1 4.17
CHEMBL5288194 1 4.15
CHEMBL5285884 1 4.13
CHEMBL5284657 1 4.12
CHEMBL5270494 1 4.12
CHEMBL5286370 1 4.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5284356 IC50 = 8210.0 nM 5.09
CHEMBL5286298 IC50 = 10090.0 nM 5.00
CHEMBL5278737 IC50 = 10950.0 nM 4.96
CHEMBL5284048 IC50 = 13610.0 nM 4.87
CHEMBL5276654 IC50 = 16950.0 nM 4.77
CHEMBL260876 THIOUREA IC50 = 20040.0 nM 4.70
CHEMBL5289402 IC50 = 20810.0 nM 4.68
CHEMBL5287120 IC50 = 22850.0 nM 4.64
CHEMBL5268072 IC50 = 27100.0 nM 4.57
CHEMBL5284254 IC50 = 29820.0 nM 4.53
CHEMBL5268337 IC50 = 44320.0 nM 4.35
CHEMBL5273256 IC50 = 52100.0 nM 4.28
CHEMBL5278896 IC50 = 54420.0 nM 4.26
CHEMBL5290409 IC50 = 60310.0 nM 4.22
CHEMBL5281292 IC50 = 67690.0 nM 4.17
CHEMBL5288194 IC50 = 71010.0 nM 4.15
CHEMBL5285884 IC50 = 74720.0 nM 4.13
CHEMBL5284657 IC50 = 76550.0 nM 4.12
CHEMBL5270494 IC50 = 75360.0 nM 4.12
CHEMBL5286370 IC50 = 92860.0 nM 4.03