Assay Detail
Binding
CHEMBL5223531
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of acid-induced fibrillogenesis of human Transthyretin Y78F mutant expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of fibril formation incubated for 30 mins by kinetic turbidimetric assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of kinetic stabilizers of tetrameric transthyretin: A prospective ligand efficiency-guided approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.22 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5284574 | — | — | 1 | 5.44 |
| CHEMBL5287212 | — | — | 1 | 5.43 |
| CHEMBL5271162 | — | — | 1 | 5.41 |
| CHEMBL1232738 | — | — | 1 | 5.38 |
| CHEMBL5278455 | — | — | 1 | 5.37 |
| CHEMBL5291276 | — | — | 1 | 5.34 |
| CHEMBL5276015 | — | — | 1 | 5.29 |
| CHEMBL5276384 | — | — | 1 | 5.28 |
| CHEMBL5278846 | — | — | 1 | 5.28 |
| CHEMBL5283682 | — | — | 1 | 5.22 |
| CHEMBL5272582 | — | — | 1 | 5.22 |
| CHEMBL5278451 | — | — | 1 | 5.21 |
| CHEMBL5270535 | — | — | 1 | 5.14 |
| CHEMBL5273376 | — | — | 1 | 5.14 |
| CHEMBL5275465 | — | — | 1 | 4.66 |
| CHEMBL5266565 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5284574 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5287212 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5271162 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1232738 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5278455 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5291276 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5276015 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5276384 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5278846 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5283682 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5272582 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5278451 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5270535 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5273376 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5275465 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL5266565 | — | IC50 | = | 23100.0 | nM | 4.64 |