Assay Detail
Functional
CHEMBL5223585
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Cytotoxicity against human SUM159PT cells assessed as cell growth inhibition measured after 72 hrs by MTS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SUM-159-PT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Proteases and Their Modulators in Cancer Therapy: Challenges and Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.29 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5290620 | — | — | 1 | 8.13 |
| CHEMBL5287429 | — | — | 1 | 7.96 |
| CHEMBL5275131 | — | — | 1 | 7.85 |
| CHEMBL5283010 | — | — | 1 | 7.24 |
| CHEMBL5287669 | — | — | 1 | 7.11 |
| CHEMBL5290082 | — | — | 1 | 7.00 |
| CHEMBL4297310 | DORDAVIPRONE | 3.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5290620 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5287429 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5275131 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5283010 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5287669 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5290082 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4297310 | DORDAVIPRONE | IC50 | = | 1700.0 | nM | 5.77 |