Assay Detail
Binding
CHEMBL5223588
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant CLpP (57 to 277 amino acids) expressed in Escherichia coli using fluorogenic peptide AC-WLA-AMC as substrate incubated for 10 mins by fluorescence based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CHEMBL4523305) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Proteases and Their Modulators in Cancer Therapy: Challenges and Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.75 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5287429 | — | — | 1 | 6.92 |
| CHEMBL5290620 | — | — | 1 | 6.92 |
| CHEMBL5283010 | — | — | 1 | 6.92 |
| CHEMBL5275131 | — | — | 1 | 6.87 |
| CHEMBL5290082 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5287429 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5290620 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5283010 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5275131 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5290082 | — | EC50 | = | 800.0 | nM | 6.10 |