Assay Detail
Binding
CHEMBL5223597
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Inhibition of human BCL6 BTP domain by ELISA assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and Beyond.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.08 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4077626 | — | — | 1 | 9.00 |
| CHEMBL5269254 | — | — | 1 | 7.50 |
| CHEMBL4075278 | — | — | 1 | 7.00 |
| CHEMBL4076344 | — | — | 1 | 6.89 |
| CHEMBL5287879 | — | — | 1 | 6.58 |
| CHEMBL5277214 | — | — | 1 | 5.52 |
| CHEMBL5275452 | — | — | 1 | - |
| CHEMBL5270561 | — | — | 1 | - |
| CHEMBL5267389 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4077626 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5269254 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4075278 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4076344 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5287879 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5277214 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5275452 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL5270561 | — | IC50 | = | 620000.0 | nM | - |
| CHEMBL5267389 | — | IC50 | = | 1500000.0 | nM | - |