Assay Detail
Binding
CHEMBL5223598
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Binding affinity to human BCL6 BTP domain assessed as dissociation constant by SPR assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and Beyond.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 6.17 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4077626 | — | — | 1 | 9.24 |
| CHEMBL4094351 | — | — | 1 | 8.19 |
| CHEMBL4077392 | — | — | 1 | 7.11 |
| CHEMBL4077836 | — | — | 1 | 6.30 |
| CHEMBL4061857 | — | — | 1 | 5.96 |
| CHEMBL4163317 | — | — | 1 | 4.36 |
| CHEMBL4069971 | — | — | 1 | 4.17 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 4.06 |
| CHEMBL4071527 | — | — | 1 | - |
| CHEMBL13589 | AMANOZINE | 2.0 | 1 | - |
| CHEMBL4175189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4077626 | — | Kd | = | 0.57 | nM | 9.24 |
| CHEMBL4094351 | — | Kd | = | 6.5 | nM | 8.19 |
| CHEMBL4077392 | — | Kd | = | 78.0 | nM | 7.11 |
| CHEMBL4077836 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL4061857 | — | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL4163317 | — | Kd | = | 44000.0 | nM | 4.36 |
| CHEMBL4069971 | — | Kd | = | 68000.0 | nM | 4.17 |
| CHEMBL1084546 | PF-00562271 | Kd | = | 88000.0 | nM | 4.06 |
| CHEMBL4071527 | — | Kd | = | 690000.0 | nM | - |
| CHEMBL13589 | AMANOZINE | Kd | = | 1200000.0 | nM | - |
| CHEMBL4175189 | — | Kd | = | 3200000.0 | nM | - |