Assay Detail
Functional
CHEMBL5223656
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Cytotoxicity against human HCC827 cells incubated for 36 hrs by standard CCK-8 assay
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Pyrrole-imidazole Polyamides as PD-L1 Expression Inhibitors and Their Anticancer Activity via Immune and Nonimmune Pathways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.88 | 5.08 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089730 | — | — | 1 | 5.08 |
| CHEMBL5268128 | — | — | 2 | 4.93 |
| CHEMBL5276924 | — | — | 2 | 4.63 |
| CHEMBL5290486 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089730 | — | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL5268128 | — | IC50 | = | 11840.0 | nM | 4.93 |
| CHEMBL5276924 | — | IC50 | = | 23230.0 | nM | 4.63 |
| CHEMBL5276924 | — | Activity | - | — | - | |
| CHEMBL5268128 | — | Activity | - | — | - | |
| CHEMBL5290486 | — | Activity | - | — | - | |
| CHEMBL5290486 | — | IC50 | > | 200000.0 | nM | - |