Assay Detail
Binding
CHEMBL5223945
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Binding affinity to human MDM4 assessed as inhibition constant
3
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 6.68 | 6.68 |
| Ki | 1 | 8.17 | 8.17 |
| IC50 | 1 | 5.52 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5290323 | — | — | 1 | 8.17 |
| CHEMBL4289676 | — | — | 1 | 6.68 |
| CHEMBL3657129 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5290323 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL4289676 | — | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL3657129 | — | IC50 | = | 3000.0 | nM | 5.52 |