Assay Detail
Binding
CHEMBL5223964
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Inhibition of human MDM4
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.50 | 7.61 |
| EC50 | 1 | 5.64 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220312 | — | — | 1 | 7.61 |
| CHEMBL5267044 | — | — | 1 | 7.39 |
| CHEMBL5286722 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220312 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL5267044 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5286722 | — | EC50 | = | 2300.0 | nM | 5.64 |