Assay Detail
Functional
CHEMBL5224092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.27 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5076091 | — | — | 1 | 7.96 |
| CHEMBL4743666 | — | — | 1 | 7.80 |
| CHEMBL5278809 | — | — | 1 | 7.55 |
| CHEMBL5287177 | — | — | 1 | 7.50 |
| CHEMBL5077043 | — | — | 1 | 7.37 |
| CHEMBL5279604 | — | — | 1 | 7.32 |
| CHEMBL5270982 | — | — | 1 | 7.12 |
| CHEMBL5288088 | — | — | 1 | 6.75 |
| CHEMBL5083562 | — | — | 1 | 6.72 |
| CHEMBL5276902 | — | — | 1 | 6.64 |
| CHEMBL5276935 | — | — | 1 | 6.35 |
| CHEMBL5081638 | — | — | 1 | 5.99 |
| CHEMBL5084830 | — | — | 1 | 5.73 |
| CHEMBL5083490 | — | — | 1 | 5.65 |
| CHEMBL5284647 | — | — | 1 | 5.58 |
| CHEMBL5287687 | — | — | 1 | 5.57 |
| CHEMBL5273486 | — | — | 1 | 5.37 |
| CHEMBL5282084 | — | — | 1 | 5.33 |
| CHEMBL5267992 | — | — | 1 | 5.26 |
| CHEMBL5282512 | — | — | 1 | 5.20 |
| CHEMBL5285875 | — | — | 1 | 4.83 |
| CHEMBL5274941 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5076091 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4743666 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5278809 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5287177 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5077043 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5279604 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5270982 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5288088 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5083562 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5276902 | — | EC50 | = | 228.0 | nM | 6.64 |
| CHEMBL5276935 | — | EC50 | = | 449.0 | nM | 6.35 |
| CHEMBL5081638 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5084830 | — | EC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL5083490 | — | EC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL5284647 | — | EC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL5287687 | — | EC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL5273486 | — | EC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL5282084 | — | EC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL5267992 | — | EC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL5282512 | — | EC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL5285875 | — | EC50 | = | 14750.0 | nM | 4.83 |
| CHEMBL5274941 | — | EC50 | = | 45850.0 | nM | 4.34 |