Assay Detail
Binding
CHEMBL5224205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LOX5 using arachidonic acid preincubated for 10 mins followed by substrate addition by microplate spectrophotometric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.68 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5270908 | — | — | 1 | 4.82 |
| CHEMBL5270046 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5270908 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5270046 | — | IC50 | = | 29000.0 | nM | 4.54 |