Assay Detail
Binding
CHEMBL5224273
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Antagonist activity at rat forebrain CB1R assessed as inhibition constant
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Forebrain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Covalent cannabinoid receptor ligands - structural insight and selectivity challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.24 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285932 | — | — | 2 | 8.13 |
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 7.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285932 | — | Ki | = | 7.49 | nM | 8.13 |
| CHEMBL111 | RIMONABANT | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL285932 | — | Ki | = | 2290.0 | nM | 5.64 |