Assay Detail
Binding
CHEMBL5224414
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Inhibition of CDK4 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
CDK9 inhibitors in cancer research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.22 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741442 | — | — | 1 | 7.21 |
| CHEMBL3905910 | VORUCICLIB | 2.0 | 1 | 7.05 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.00 |
| CHEMBL1922219 | — | — | 1 | 5.32 |
| CHEMBL5169987 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741442 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3905910 | VORUCICLIB | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1922219 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5169987 | — | IC50 | = | 30000.0 | nM | 4.52 |