Assay Detail
Binding
CHEMBL5224415
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Inhibition of CDK5 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
CDK9 inhibitors in cancer research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.18 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 8.30 |
| CHEMBL3655762 | CYC-065 | 2.0 | 1 | 7.68 |
| CHEMBL1922219 | — | — | 1 | 7.16 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 6.77 |
| CHEMBL3905910 | VORUCICLIB | 2.0 | 1 | 6.68 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3655762 | CYC-065 | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1922219 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3905910 | VORUCICLIB | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 340.0 | nM | 6.47 |