Assay Detail

CHEMBL5224423

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Binding

Inhibition of CDK8 (unknown origin)

ChEMBL ↗

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Target

Cyclin-dependent kinase 8 (CHEMBL5719) ↗

Open DB target context

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Cyclin-dependent kinase 8 (CHEMBL5719) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cyclin-dependent kinase 8

CHEMBL5719

Anchored from Assay target.

Protein identity Cyclin-dependent kinase 8

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cyclin-dependent kinase 8 (CHEMBL5719) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

CDK9 inhibitors in cancer research.

Huang Z, Wang T, Wang C, Fan Y.
RSC Med Chem (2022) 13 : 688 -710
PubMed 35814933 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.92	7.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3905910	VORUCICLIB	2.0	1	7.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3905910	VORUCICLIB	IC50	=	12.0	nM	7.92