Assay Detail

CHEMBL5224428

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Binding

Binding affinity to CDK9 (unknown origin) by KINOMEscan method

ChEMBL ↗

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Target

Cyclin-dependent kinase 9 (CHEMBL3116) ↗

Open DB target context

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Cyclin-dependent kinase 9 (CHEMBL3116) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cyclin-dependent kinase 9

CHEMBL3116

Anchored from Assay target.

Protein identity Cyclin-dependent kinase 9

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cyclin-dependent kinase 9 (CHEMBL3116) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

CDK9 inhibitors in cancer research.

Huang Z, Wang T, Wang C, Fan Y.
RSC Med Chem (2022) 13 : 688 -710
PubMed 35814933 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.40	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4754493	BTX-A51	1.0	1	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4754493	BTX-A51	IC50	=	4.0	nM	8.40