Assay Detail
Toxicity
CHEMBL5224826
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Cytotoxicity against human HepG2 cells by SRB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel N, N'-diarylurea derivatives as potent antibacterial agents against MRSA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.00 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636848 | — | — | 1 | 5.25 |
| CHEMBL5290828 | — | — | 1 | 5.20 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.18 |
| CHEMBL5267302 | — | — | 1 | 5.15 |
| CHEMBL1981438 | CLOFLUCARBAN | 2.0 | 1 | 5.11 |
| CHEMBL530543 | — | — | 1 | 5.11 |
| CHEMBL5273588 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636848 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL5290828 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL5267302 | — | IC50 | = | 7090.0 | nM | 5.15 |
| CHEMBL1981438 | CLOFLUCARBAN | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL530543 | — | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL5273588 | — | IC50 | = | 99990.0 | nM | 4.00 |