Assay Detail
Functional
CHEMBL5224837
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Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 3 days by CellTiter-Glo Luminescent assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrrolo[2,3-d]pyrimidine-based molecules as a Wee1 inhibitor template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.93 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5284925 | — | — | 1 | 7.64 |
| CHEMBL5290439 | — | — | 1 | 7.48 |
| CHEMBL5289843 | — | — | 1 | 7.38 |
| CHEMBL5282382 | — | — | 1 | 7.38 |
| CHEMBL5284989 | — | — | 1 | 7.37 |
| CHEMBL5278196 | — | — | 1 | 7.27 |
| CHEMBL5269524 | — | — | 1 | 7.23 |
| CHEMBL5281278 | — | — | 1 | 7.17 |
| CHEMBL5279297 | — | — | 1 | 7.06 |
| CHEMBL5279054 | — | — | 1 | 7.04 |
| CHEMBL5278751 | — | — | 1 | 7.00 |
| CHEMBL5288235 | — | — | 1 | 7.00 |
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 6.98 |
| CHEMBL5279737 | — | — | 1 | 6.98 |
| CHEMBL5273079 | — | — | 1 | 6.90 |
| CHEMBL5279123 | — | — | 1 | 6.81 |
| CHEMBL5199347 | — | — | 1 | 6.70 |
| CHEMBL5270034 | — | — | 1 | 6.68 |
| CHEMBL5267467 | — | — | 1 | 6.54 |
| CHEMBL5267186 | — | — | 1 | 6.48 |
| CHEMBL5290782 | — | — | 1 | 6.35 |
| CHEMBL5192067 | — | — | 1 | 6.21 |
| CHEMBL5288823 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5284925 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5290439 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5289843 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5282382 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5284989 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5278196 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5269524 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5281278 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5279297 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5279054 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL5278751 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5288235 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5279737 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL5273079 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL5279123 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5199347 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL5270034 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL5267467 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL5267186 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL5290782 | — | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL5192067 | — | IC50 | = | 623.0 | nM | 6.21 |
| CHEMBL5288823 | — | IC50 | = | 1719.0 | nM | 5.76 |