Assay Detail
Binding
CHEMBL5224985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav1.5 in inactivated condition by automated patch-clamp assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 5 subunit alpha (CHEMBL1980) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of Na<sub>V</sub>1.7: the possibility of ideal analgesics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.56 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558 | MEXILETINE | 4.0 | 1 | 4.82 |
| CHEMBL79 | LIDOCAINE | 4.0 | 1 | 4.30 |
| CHEMBL5275826 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558 | MEXILETINE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL79 | LIDOCAINE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5275826 | — | IC50 | > | 100000.0 | nM | - |