Assay Detail
Binding
CHEMBL5225007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav1.7 at -60 mV holding potential by manual patch-clamp assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 9 subunit alpha (CHEMBL4296) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of Na<sub>V</sub>1.7: the possibility of ideal analgesics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.68 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061793 | — | — | 1 | 8.51 |
| CHEMBL4471012 | — | — | 1 | 7.82 |
| CHEMBL4444707 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061793 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4471012 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL4444707 | — | IC50 | = | 192.0 | nM | 6.72 |