Assay Detail

CHEMBL5225019

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of rhesus monkey Nav1.7 at voltage yielding 20% channel inactivation by manual patch-clamp assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Macaca mulatta
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Inhibition of Na<sub>V</sub>1.7: the possibility of ideal analgesics.

Kitano Y, Shinozuka T.
RSC Med Chem (2022) 13 : 895 -920
PubMed 36092147 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.28	6.53

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5289676	—	—	1	6.53
CHEMBL2325014	PF-05089771	2.0	1	6.03

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5289676	—	IC50	=	295.0	nM	6.53
CHEMBL2325014	PF-05089771	IC50	=	926.0	nM	6.03