Assay Detail
Functional
CHEMBL5225146
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Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell viability
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of mixed σ<sub>1</sub>R/σ<sub>2</sub>R ligands with antiproliferative and anticancer effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.13 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279451 | — | — | 1 | 5.89 |
| CHEMBL5291247 | — | — | 1 | 5.07 |
| CHEMBL3104857 | — | — | 1 | 4.88 |
| CHEMBL3104856 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279451 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL5291247 | — | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL3104857 | — | IC50 | = | 13040.0 | nM | 4.88 |
| CHEMBL3104856 | — | IC50 | = | 21320.0 | nM | 4.67 |