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Assay Detail

CHEMBL5225167

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human MMP2
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

72 kDa type IV collagenase (CHEMBL333)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A review of MMP-2 structures and binding mode analysis of its inhibitors to strategize structure-based drug design.
Sanyal S, Amin SA, Banerjee P, Gayen S, Jha T.
Bioorg Med Chem (2022) 74 : 117044 -117044
PubMed 36244233 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.64 7.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5283314 1 7.57
CHEMBL460657 ELAIDIC ACID 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5283314 IC50 = 27.0 nM 7.57
CHEMBL460657 ELAIDIC ACID IC50 = 1995.0 nM 5.70