Assay Detail
Binding
CHEMBL5225231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PKR (unknown origin)
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Interferon-induced, double-stranded RNA-activated protein kinase (CHEMBL5785) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of potent and selective inhibitors of PKR via virtual screening and traditional design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.33 | 6.94 |
| EC50 | 2 | 7.23 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279578 | — | — | 1 | 7.43 |
| CHEMBL5286788 | — | — | 1 | 7.02 |
| CHEMBL4281823 | — | — | 1 | 6.94 |
| CHEMBL5271785 | — | — | 1 | 6.51 |
| CHEMBL5266620 | — | — | 1 | 6.44 |
| CHEMBL5280116 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279578 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5286788 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4281823 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL5271785 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL5266620 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL5280116 | — | IC50 | = | 3880.0 | nM | 5.41 |