Assay Detail
Functional
CHEMBL5225283
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Antiviral activity against ectromelia virus K-1 infected in Vero cells measured after 4 days by colorimetric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ectromelia virus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.46 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5269665 | — | — | 1 | 8.12 |
| CHEMBL5277808 | — | — | 1 | 5.97 |
| CHEMBL5280323 | — | — | 1 | 5.17 |
| CHEMBL5266864 | — | — | 1 | 5.05 |
| CHEMBL5285582 | — | — | 1 | 4.83 |
| CHEMBL5288296 | — | — | 1 | 4.63 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5269665 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5277808 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5280323 | — | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL5266864 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5285582 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL5288296 | — | IC50 | = | 23630.0 | nM | 4.63 |
| CHEMBL5314375 | CIDOFOVIR | IC50 | = | 33980.0 | nM | 4.47 |