Assay Detail
Functional
CHEMBL5225526
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of pyrido.[3,4-b]pyrazin-2(1H)-one derivatives as potent FLT3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.66 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 9.68 |
| CHEMBL5271605 | — | — | 1 | 7.82 |
| CHEMBL5287072 | — | — | 1 | 7.62 |
| CHEMBL5273130 | — | — | 1 | 7.58 |
| CHEMBL5288494 | — | — | 1 | 7.52 |
| CHEMBL5268304 | — | — | 1 | 7.51 |
| CHEMBL5276264 | — | — | 1 | 7.44 |
| CHEMBL5282636 | — | — | 1 | 7.28 |
| CHEMBL5265945 | — | — | 1 | 7.17 |
| CHEMBL5289344 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL5271605 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5287072 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5273130 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5288494 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5268304 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5276264 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5282636 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5265945 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5289344 | — | IC50 | = | 98.0 | nM | 7.01 |