Assay Detail
Binding
CHEMBL5225826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged recombinant Neisseria gonorrhoeae alpha carbonic anhydrase assessed as inhibition constant by stopped-flow CO2 hydration assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Neisseria gonorrhoeae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to <i>Neisseria gonorrhoeae</i> α-Carbonic Anhydrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.57 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4782535 | — | — | 1 | 9.15 |
| CHEMBL4741159 | — | — | 1 | 8.08 |
| CHEMBL4739913 | — | — | 1 | 8.01 |
| CHEMBL4750765 | — | — | 1 | 7.44 |
| CHEMBL4753745 | — | — | 1 | 7.38 |
| CHEMBL5280695 | — | — | 1 | 7.18 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.13 |
| CHEMBL265674 | — | — | 1 | 7.13 |
| CHEMBL4749585 | — | — | 1 | 7.13 |
| CHEMBL281376 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4782535 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4741159 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL4739913 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL4750765 | — | Ki | = | 36.6 | nM | 7.44 |
| CHEMBL4753745 | — | Ki | = | 42.1 | nM | 7.38 |
| CHEMBL5280695 | — | Ki | = | 65.7 | nM | 7.18 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 74.1 | nM | 7.13 |
| CHEMBL265674 | — | Ki | = | 73.2 | nM | 7.13 |
| CHEMBL4749585 | — | Ki | = | 73.9 | nM | 7.13 |
| CHEMBL281376 | — | Ki | = | 78.6 | nM | 7.11 |