Assay Detail
Binding
CHEMBL5225827
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Inhibition of human carbonic anhydrase 2 assessed as inhibition constant by stopped-flow CO2 hydration assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to <i>Neisseria gonorrhoeae</i> α-Carbonic Anhydrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.74 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4782535 | — | — | 1 | 9.49 |
| CHEMBL4741159 | — | — | 1 | 8.09 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.90 |
| CHEMBL4739913 | — | — | 1 | 7.70 |
| CHEMBL4750765 | — | — | 1 | 7.61 |
| CHEMBL281376 | — | — | 1 | 7.54 |
| CHEMBL5280695 | — | — | 1 | 7.42 |
| CHEMBL4749585 | — | — | 1 | 7.33 |
| CHEMBL265674 | — | — | 1 | 7.22 |
| CHEMBL4753745 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4782535 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL4741159 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL4739913 | — | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL4750765 | — | Ki | = | 24.5 | nM | 7.61 |
| CHEMBL281376 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL5280695 | — | Ki | = | 38.3 | nM | 7.42 |
| CHEMBL4749585 | — | Ki | = | 47.2 | nM | 7.33 |
| CHEMBL265674 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL4753745 | — | Ki | = | 78.4 | nM | 7.11 |