Assay Detail
Functional
CHEMBL5225883
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Anti-osteoclastogensis activity in BALB/c mouse bone marrow macrophage cells assessed as inhibition of RANKL/M-CSF-induced osteoclastogenesis by measuring osteoclasts number incubated for 11 days by TRAP staining based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of pyrazole-fused oleanolic acid derivatives as novel inhibitors of inflammatory and osteoclast differentiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.33 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5270204 | — | — | 1 | 5.59 |
| CHEMBL5265923 | — | — | 1 | 5.57 |
| CHEMBL5290776 | — | — | 1 | 5.57 |
| CHEMBL5277425 | — | — | 1 | 5.42 |
| CHEMBL5275936 | — | — | 1 | 5.39 |
| CHEMBL5266874 | — | — | 1 | 5.30 |
| CHEMBL5273423 | — | — | 1 | 5.07 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5270204 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL5265923 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL5290776 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL5277425 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL5275936 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5266874 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL5273423 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 18640.0 | nM | 4.73 |