Assay Detail
Binding
CHEMBL5225971
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Antagonist activity at human 5HT3A expressed in HEK293 cells incubated for 1 hr by FLIPR assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.85 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5272946 | — | — | 1 | 6.65 |
| CHEMBL5278405 | — | — | 1 | 6.47 |
| CHEMBL5278640 | — | — | 1 | 6.23 |
| CHEMBL5273314 | — | — | 1 | 5.80 |
| CHEMBL5275403 | — | — | 1 | 5.71 |
| CHEMBL5286066 | — | — | 1 | 5.66 |
| CHEMBL5286071 | — | — | 1 | 5.61 |
| CHEMBL5288633 | — | — | 1 | 5.38 |
| CHEMBL5278676 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5272946 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL5278405 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL5278640 | — | IC50 | = | 585.0 | nM | 6.23 |
| CHEMBL5273314 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL5275403 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL5286066 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL5286071 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5288633 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL5278676 | — | IC50 | = | 7470.0 | nM | 5.13 |